This might sound a little bit ghoulish, but I've often wondered if it would be possible to extract any DNA from Queen Victoria's remains in efforts to prove that she had inherited the genes for hemophilia. I've seen two theories: one that hemophilia arose in the BRF as a result of a mutation in Queen Victoria. (Have even seen a cosmic-ray hit on her ovaries as the reason). The other theory is that there were instances of the disorder in her maternal line. Since they can now pretty clearly identify the genes responsible, I would be curious about that.
The hemophilia inheritence in the offspring of QV is a fine school/studies example, as it relatively well documented and good to follow in the lineage. I often encoutered it during (basic) genetic classes.
In the past it has been suggested that QV was not the biological child of the Duke of Kent, as the disease was not noticed/seen before in the royal lineage. And as it seemed another disease dissapeared after QV (porphyria) The English language Wikipedia about hemophilia in European royals provide clear arguments against and clear explanation with regard to the hemophilia https://en.wikipedia.org/...hilia_in_European_royalty
"...Although an individual's haemophilia can usually be traced in the ancestry, in about 30% of cases there is no family history of the disorder and the condition is speculated to be the result of spontaneous mutation in an ancestor.
Victoria appears to have been a spontaneous or de novo mutation and is usually considered the source of the disease in modern cases of haemophilia among royalty. Queen Victoria's father, Prince Edward, Duke of Kent, was not a haemophiliac, and the probability of her mother having had a lover who suffered from haemophilia is minuscule given the low life expectancy of 19th-century haemophiliacs. Her mother, Victoria, Duchess of Kent, was not known to have a family history of the disease, although it is possible that the mutation began at her conception and was passed down only to Victoria and not to her two other children. In the same way, had Queen Victoria herself only had seven children, the mutation would probably be assumed today to have occurred at the conception of Princess Alice, as she was the only known carrier among Victoria and Albert's first seven children.
Queen Victoria's eldest daughter, Victoria, Princess Royal, apparently escaped the haemophilia gene as it did not appear in any of her matrilineal descendants. Victoria's fifth child, Helena, may or may not have been a carrier; two healthy sons survived to adulthood but two other sons died in infancy and her two daughters did not have issue. Victoria's sixth child, Louise, died without issue. Her sons Edward, Alfred, and Arthur were not haemophiliacs. However, her daughters Alice and Beatrice were confirmed carriers of the gene, and her son Leopold was a sufferer of haemophilia, making his daughter Princess Alice, Countess of Athlone a carrier as well...."
"...No living member of the present or past reigning dynasties of Europe is known to have symptoms of haemophilia or is believed to carry the gene for it. The last descendant of Victoria known to suffer from the disease was Infante Don Gonzalo, born in 1914, although dozens of descendants of Queen Victoria's (including males descended only through females) have been born since 1914. However, because the haemophilia gene usually remains hidden in females who only inherit the gene from one parent, and female descendants of Victoria have left many descendants in royal and noble families, there remains a small chance that the disease could appear again, especially among the female-line Spanish descendants of Princess Beatrice...."
"...Because the last known descendant of Queen Victoria with haemophilia died in the 1940s, the exact type of haemophilia found in this family remained unknown until 2009. Using genetic analysis of the remains of the assassinated Romanov dynasty, and specifically Tsarevich Alexei, Rogaev et al. were able to determine that the "Royal Disease" is actually haemophilia B
. Specifically, they found a single-nucleotide change in the gene for clotting Factor IX that causes incorrect RNA splicing and produces a truncated, nonfunctional protein..."