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Chandrasekhi
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« Last Edit: April 09, 2020, 02:07:29 PM by Chandrasekhi »
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“Do or do not. There is no try.”
– Yoda
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Principessa
Most Exalted Member
Reputation: 1723
 Offline
 Netherlands
Posts: 23068
I am the Queen
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Recently I encountered the following book (the Dutch version) in my collection of books. I stumbled upon it about 5-6 years ago, and bought it based on personal interest and my former studies. The English original is of 2012 and among others has a part about the SARS item (and also has references to the Mexican flu. I have only read small parts of this book before it ended up on my very large TBR pile. But currently it is very actual again and his started reading it yesterday. Discussing it online also resultated in friends and other contacts to obtain the book and reading it (in particular those with a similar background with regard to studies and or profession in the area). David Quammen - Spillover: Animal Infections and the Next Human Pandemic Scientific American Podcast: https://www.scientificame...ons-spill-over-to-humans/In this 2012 interview, David Quammen talks about his book Spillover: Animal Infections and the Next Human Pandemic, which is highly relevant to the emergence of the coronavirus that has changed our lives. |
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Chandrasekhi
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https://www.cochrane.org/https://www.cochranelibrary.com/covid-19About us
Cochrane is for anyone interested in using high-quality information to make health decisions. Whether you are a doctor or nurse, patient or carer, researcher or funder, Cochrane evidence provides a powerful tool to enhance your healthcare knowledge and decision making.
Cochrane’s 11,000 members and over 68,000 supporters come from more than 130 countries, worldwide. Our volunteers and contributors are researchers, health professionals, patients, carers, and people passionate about improving health outcomes for everyone, everywhere. Our global independent network gathers and summarizes the best evidence from research to help you make informed choices about treatment and we have been doing this for 25 years.
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« Last Edit: April 12, 2020, 01:11:18 PM by Chandrasekhi »
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“Do or do not. There is no try.”
– Yoda
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Chandrasekhi
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https://www.cochrane.org/https://www.cochranelibrary.com/covid-19About us
Cochrane is for anyone interested in using high-quality information to make health decisions. Whether you are a doctor or nurse, patient or carer, researcher or funder, Cochrane evidence provides a powerful tool to enhance your healthcare knowledge and decision making.
Cochrane’s 11,000 members and over 68,000 supporters come from more than 130 countries, worldwide. Our volunteers and contributors are researchers, health professionals, patients, carers, and people passionate about improving health outcomes for everyone, everywhere. Our global independent network gathers and summarizes the best evidence from research to help you make informed choices about treatment and we have been doing this for 25 years.
https://www.cochranelibra.../central/CN-02048963/full"Zinc Supplementation Promotes a Th1 Response and Improves Clinical Symptoms in Fewer Hours in Children With Pneumonia Younger Than 5 Years Old. A Randomized Controlled Clinical Trial"
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Conclusions: Zinc supplementation improved some clinical symptoms in children with pneumonia in fewer hours and induced a cellular immune response. |
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“Do or do not. There is no try.”
– Yoda
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Chandrasekhi
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« Last Edit: April 15, 2020, 11:54:16 PM by Chandrasekhi »
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– Yoda
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Chandrasekhi
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CYTOKINE STORMDEFINITION https://www.forbes.com/si...e-treatment-for-covid-19/a cytokine storm is an extreme immune response of your own body. When coronavirus (SARS-CoV-2) enters the lungs, your immune system responds with virus-fighting cells that release small proteins called cytokines. In some cases, the immune system just keeps amplifying its response, sending more and more cytokines even though the infection might be under control. If it gets too bad, the cytokine storm itself may be fatal. Cytokine storms have been implicated in other viral diseases, including influenza and SARS.
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« Last Edit: April 16, 2020, 10:56:53 AM by Chandrasekhi »
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“Do or do not. There is no try.”
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Chandrasekhi
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CYTOKINE STORM2. https://www.ncbi.nlm.nih..../pmc/articles/PMC5224679/Abstract
The increasing insight into pathomechanisms of dysregulated host response in several inflammatory diseases led to the implementation of the term “cytokine storm” in the literature more than 20 years ago. Direct toxic effects as well as indirect immunomodulatory mechanisms during cytokine storm have been described and were the basis for the rationale to use several substances and devices in life-threatening infections and hyperinflammatory states. Clinical trials have been performed, most of them in the form of minor, investigator-initiated protocols; major clinical trials focused mostly on sepsis and septic shock. The following review tries to summarize the background, pathophysiology, and results of clinical investigations that had implications for the development of therapeutic strategies and international guidelines for the management of hyperinflammation during syndromes of cytokine storm in adult patients, predominantly in septic shock.
Keywords: cytokine storm, sepsis, septic shock, hyperinflammation
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“Do or do not. There is no try.”
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Chandrasekhi
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CYTOKINE STORM3. https://www.ncbi.nlm.nih.gov/pubmed/32234467The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality.
Abstract
Since December 2019, a viral pneumonia (COVID-19) from Wuhan, China has swept the world. Although the case fatality rate is not high, the number of people infected is large, and there are still a large number of patients dying. With the collation and publication of more and more clinical data, a large number of data suggest that there are mild or severe cytokine storms in severe patients, which is also an important cause of death. Therefore, the treatment of cytokine storm has become an important part of rescuing severe patients. Interleukin-6 (IL-6) plays an important role in cytokine release syndrome (CRS). If it can block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe patients. Tocilizumab is a blocker of IL-6R, which can effectively block IL-6 signal transduction pathway. So, tocilizumab is likely to become an effective drug for patients with severe COVID-19.
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“Do or do not. There is no try.”
– Yoda
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Chandrasekhi
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CYTOKINE STORM4. https://www.salon.com/202...s-dreaded-cytokine-storm/... Not everyone who experiences a cytokine storm will die, fortunately. Such is the case of Jonathan Raskin, a 69-year-old pulmonologist who practices medicine in New York City, and who contracted coronavirus a few weeks ago and is currently in recovery. |
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“Do or do not. There is no try.”
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https://www.annualreviews...ev-virology-012420-022445Keywordsrespiratory infection, antiviral immune responses, temperature, humidity,seasonality, indoor climate, outdoor climateAbstractThe seasonal cycle of respiratory viral diseases has been widely recognizedfor thousands of years, as annual epidemics of the common cold and in-fluenza disease hit the human population like clockwork in the winter sea-son in temperate regions. Moreover, epidemics caused by viruses such assevere acute respiratory syndrome coronavirus (SARS-CoV) and the newlyemerging SARS-CoV-2 occur during the winter months. The mechanismsunderlying the seasonal nature of respiratory viral infections have been ex-amined and debated for many years. The two major contributing factors arethe changes in environmental parameters and human behavior. Studies haverevealed the effect of temperature and humidity on respiratory virus stabilityand transmission rates. More recent research highlights the importance ofthe environmental factors, especially temperature and humidity, in modulat-ing host intrinsic, innate, and adaptive immune responses to viral infectionsin the respiratory tract. Here we review evidence of how outdoor and indoorclimates are linked to the seasonality of viral respiratory infections. We fur-ther discuss determinants of host response in the seasonality of respiratoryviruses by highlighting recent studies in the fie
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